Analysis of H3K4me3 and H3K27me3 bivalent promotors in HER2+ breast cancer cell lines reveals variations depending on estrogen receptor status and significantly correlates with gene expression

• Auteurs principaux: Damien Kaukonen (Auteur), Riina Kaukonen (Auteur), Lélia Polit (Auteur), Bryan T. Hennessy (Auteur), Riikka Lund (Auteur), Stephen F. Madden (Auteur)
• Format: Livre
• Publié: BMC, 2020-07-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

Abstract Background The role of histone modifications is poorly characterized in breast cancer, especially within the major subtypes. While epigenetic modifications may enhance the adaptability of a cell to both therapy and the surrounding environment, the mechanisms by which this is accomplished re...