Novel Targeted Therapy for Precursor B-Cell Acute Lymphoblastic Leukemia: Anti-CD22 Antibody-MXD3 Antisense Oligonucleotide Conjugate

• Main Authors: Noriko Satake (Author), Connie Duong (Author), Sakiko Yoshida (Author), Michael Oestergaard (Author), Cathy Chen (Author), Rachael Peralta (Author), Shuling Guo (Author), Punit P Seth (Author), Yueju Li (Author), Laurel Beckett (Author), Jong Chung (Author), Jan Nolta (Author), Nitin Nitin (Author), Joseph M Tuscano (Author)
• Format: Book
• Published: BMC, 2016-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract The exponential rise in molecular and genomic data has generated a vast array of therapeutic targets. Oligonucleotide-based technologies to down regulate these molecular targets have promising therapeutic efficacy. However, there is relatively limited success in translating this into effect...