Development of certain benzylidene coumarin derivatives as anti-prostate cancer agents targeting EGFR and PI3Kβ kinases

• Main Authors: Lina M. A. Abdel Ghany (Author), Tarek S. Ibrahim (Author), Abdulrahman S. Alharbi (Author), Mohamed S. Abdel-Aziz (Author), Eman M. El-labbad (Author), Mohamed Elagawany (Author), Noha Ryad (Author)
• Format: Book
• Published: Taylor & Francis Group, 2024-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

AbstractNovel coumarin derivatives were synthesised and tested for their cytotoxicity against human cancer cells (PC-3 and MDA-MB-231). Compounds 5, 4b, and 4a possessed potent cytotoxic activity against PC-3 cells with IC50 3.56, 8.99, and 10.22 µM, respectively. Compound 4c displayed cytotoxicity...