Mechanism of Heshouwuyin inhibiting the Cyt c/Apaf-1/Caspase-9/Caspase-3 pathway in spermatogenic cell apoptosis

• Main Authors: Hongjie Wang (Author), Juan Zhu (Author), Liping Jiang (Author), Boying Shan (Author), Peihan Xiao (Author), Jiayi Ai (Author), Na Li (Author), Feng Qi (Author), Siyun Niu (Author)
• Format: Book
• Published: BMC, 2020-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background The Chinese herbal compound Heshouwuyin has been shown to downregulate the apoptotic rate of testicular tissue cells in Wistar naturally aging rats, and this effect might be related to the mitochondrial pathway [15]. Apoptotic protease activating factor-1 (Apaf-1) is a major comp...