Drug Solubility Enhancement through the Preparation of Multicomponent Organic Materials: Eutectics of Lovastatin with Carboxylic Acids

• Main Authors: Andrea Mariela Araya-Sibaja (Author), José Roberto Vega-Baudrit (Author), Teodolito Guillén-Girón (Author), Mirtha Navarro-Hoyos (Author), Silvia Lucia Cuffini (Author)
• Format: Book
• Published: MDPI AG, 2019-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Lovastatin (LOV) is a drug used to treat hypercholesterolemia. Recent studies have identified its antioxidant effects and potential use in the treatment of some types of cancer. However, the low bioavailability related to its poor water solubility limits its use in solid oral dosage forms. Therefore...