E2F1 promotes hepatic gluconeogenesis and contributes to hyperglycemia during diabetes

• Main Authors: Albert Giralt (Author), Pierre-Damien Denechaud (Author), Isabel C. Lopez-Mejia (Author), Brigitte Delacuisine (Author), Emilie Blanchet (Author), Caroline Bonner (Author), Francois Pattou (Author), Jean-Sébastien Annicotte (Author), Lluis Fajas (Author)
• Format: Book
• Published: Elsevier, 2018-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Aberrant hepatic glucose production contributes to the development of hyperglycemia and is a hallmark of type 2 diabetes. In a recent study, we showed that the transcription factor E2F1, a component of the cell cycle machinery, contributes to hepatic steatosis through the transcriptional...