Molecular mechanism of sphingosine-1-phosphate action in Duchenne muscular dystrophy

• Principais autores: Diem-Hang (Autor), Nitai C. Hait (Autor), Henrik Sperber (Autor), Junlin Qi (Autor), Karin Fischer (Autor), Nick Ieronimakis (Autor), Mario Pantoja (Autor), Aislinn Hays (Autor), Jeremy Allegood (Autor), Morayma Reyes (Autor), Sarah Spiegel (Autor), Hannele Ruohola-Baker (Autor)
• Formato: Livro
• Publicado em: The Company of Biologists, 2014-01-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Duchenne muscular dystrophy (DMD) is a lethal muscle-wasting disease. Studies in Drosophila showed that genetic increase of the levels of the bioactive sphingolipid sphingosine-1-phosphate (S1P) or delivery of 2-acetyl-5-tetrahydroxybutyl imidazole (THI), an S1P lyase inhibitor, suppresses dystrophi...