Opipramol Inhibits Lipolysis in Human Adipocytes without Altering Glucose Uptake and Differently from Antipsychotic and Antidepressant Drugs with Adverse Effects on Body Weight Control

• Main Authors: Christian Carpéné (Author), Francisco Les (Author), Josep Mercader (Author), Saioa Gomez-Zorita (Author), Jean-Louis Grolleau (Author), Nathalie Boulet (Author), Jessica Fontaine (Author), Mari Carmen Iglesias-Osma (Author), Maria José Garcia-Barrado (Author)
• Format: Book
• Published: MDPI AG, 2020-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Treatment with several antipsychotic drugs exhibits a tendency to induce weight gain and diabetic complications. The proposed mechanisms by which the atypical antipsychotic drug olanzapine increases body weight include central dysregulations leading to hyperphagia and direct peripheral impairment of...