Effects of membrane transport activity and cell metabolism on the unbound drug concentrations in the skeletal muscle and liver of drugs: A microdialysis study in rats

• Main Authors: Shuyao Wang (Author), Chun Chen (Author), Chi Guan (Author), Liping Qiu (Author), Lei Zhang (Author), Shaofeng Zhang (Author), Hongyu Zhou (Author), Hongwen Du (Author), Chen Li (Author), Yaqiong Wu (Author), Hang Chang (Author), Tao Wang (Author)
• Format: Book
• Published: Wiley, 2021-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract The unbound concentrations of 14 commercial drugs, including five non‐efflux/uptake transporter substrates-Class I, five efflux transporter substrates-class II and four influx transporter substrates-Class III, were simultaneously measured in rat liver, muscle, and blood via microanalysis. K...