Receptor tyrosine kinase C-kit promotes a destructive phenotype of FLS in osteoarthritis via intracellular EMT signaling

Abstract Background Chronic inflammation, mainly derived from fibroblast-like synoviocytes (FLSs), plays a central role in the pathomechanism of osteoarthritis (OA). Recently, epithelial-mesenchymal transition (EMT) signaling was found to be activated in OA-derived FLSs with a pro-inflammatory pheno...

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Main Authors: Xu Cao (Author), Song Wu (Author), Xinxing Wang (Author), Junjie Huang (Author), Wenxiu Zhang (Author), Chi Liang (Author)
Format: Book
Published: BMC, 2023-03-01T00:00:00Z.
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