PLGA Microspheres with Alginate-Coated Large Pores for the Formulation of an Injectable Depot of Donepezil Hydrochloride

• Main Authors: Dohyun Kim (Author), Tae Hee Han (Author), Seong-Chul Hong (Author), Sun Jae Park (Author), Yong Hak Lee (Author), Hyeongmin Kim (Author), Minwoo Park (Author), Jaehwi Lee (Author)
• Format: Book
• Published: MDPI AG, 2020-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

As the main symptom of Alzheimer's disease-related dementia is memory loss, patient compliance for donepezil hydrochloride (donepezil), administered as once-daily oral formulations, is poor. Thus, we aimed to design poly(lactic-<i>co</i>-glycolic acid) (PLGA) microspheres (MS) with...