Discovery of Indole-Containing Benzamide Derivatives as HDAC1 Inhibitors with In Vitro and In Vivo Antitumor Activities

• Main Authors: Xiu Gu (Author), Xin-Yan Peng (Author), Hao Zhang (Author), Bo Han (Author), Min-Ru Jiao (Author), Qiu-Shi Chen (Author), Qing-Wei Zhang (Author)
• Format: Book
• Published: Georg Thieme Verlag KG, 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Targeting histone deacetylases (HDACs) has become an important focus in cancer inhibition. The pharmacophore of HDAC inhibitors (HDACis) reported so far is composed of three parts: a zinc-binding group (ZBG), a hydrophobic cavity-binding linker, and a surface-recognition cap interacting wit...