Cucurbitacin B induces inhibitory effects via the CIP2A/PP2A/C-KIT signaling axis in t(8;21) acute myeloid leukemia

• Egile Nagusiak: Wenjing Ma (Egilea), Yuchen Xiang (Egilea), Rui Yang (Egilea), Te Zhang (Egilea), Jiaxin Xu (Egilea), Yezi Wu (Egilea), Xuewen Liu (Egilea), Ke Xiang (Egilea), Huzi Zhao (Egilea), Ying Liu (Egilea), Yuan Si (Egilea)
• Formatua: Liburua
• Argitaratua: Elsevier, 2019-04-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Acute myeloid leukemia (AML) is the most common subtype of hematological malignancy in humans, and its incidence increases with age. The treatment of AML still faces challenges. Therefore, there is an urgent need to develop more effective targeted therapies. The receptor tyrosine kinase C-KIT confer...