Amyloid β-Oligomers Inhibit the Nuclear Ca²⁺ Signals and the Neuroprotective Gene Expression Induced by Gabazine in Hippocampal Neurons

• Main Authors: Pedro Lobos (Author), Ignacio Vega-Vásquez (Author), Barbara Bruna (Author), Silvia Gleitze (Author), Jorge Toledo (Author), Steffen Härtel (Author), Cecilia Hidalgo (Author), Andrea Paula-Lima (Author)
• Format: Book
• Published: MDPI AG, 2023-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Hippocampal neuronal activity generates dendritic and somatic Ca²⁺ signals, which, depending on stimulus intensity, rapidly propagate to the nucleus and induce the expression of transcription factors and genes with crucial roles in cognitive functions. Soluble amyloid-beta oli...