Dopamine D2 antagonist-induced striatal Nur77 expression requires activation of mGlu5 receptors by cortical afferents

• Main Authors: Jérôme eMaheux (Author), Michel eSt-Hilaire (Author), David eVoyer (Author), Emanuele eTirotta (Author), Emiliana eBorrelli (Author), Claude eRouillard (Author), Pierre-Paul eRompré (Author), Daniel eLévesque (Author)
• Format: Book
• Published: Frontiers Media S.A., 2012-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Dopamine D2 receptor antagonists modulate gene transcription in the striatum. However, the molecular mechanism underlying this effect remains elusive. Here we used the expression of Nur77, a transcription factor of the orphan nuclear receptor family, as readout to explore the role of dopamine, gluta...