Dopamine D2 antagonist-induced striatal Nur77 expression requires activation of mGlu5 receptors by cortical afferents

• Главные авторы: Jérôme eMaheux (Автор), Michel eSt-Hilaire (Автор), David eVoyer (Автор), Emanuele eTirotta (Автор), Emiliana eBorrelli (Автор), Claude eRouillard (Автор), Pierre-Paul eRompré (Автор), Daniel eLévesque (Автор)
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• Опубликовано: Frontiers Media S.A., 2012-08-01T00:00:00Z.
• Предметы: article
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Dopamine D2 receptor antagonists modulate gene transcription in the striatum. However, the molecular mechanism underlying this effect remains elusive. Here we used the expression of Nur77, a transcription factor of the orphan nuclear receptor family, as readout to explore the role of dopamine, gluta...