Glycaemia and body weight are regulated by sodium-glucose cotransporter 1 (SGLT1) expression via O-GlcNAcylation in the intestine

• Main Authors: Kimihiro Nishimura (Author), Yukihiro Fujita (Author), Shogo Ida (Author), Tsuyoshi Yanagimachi (Author), Natsuko Ohashi (Author), Kiyoto Nishi (Author), Atsushi Nishida (Author), Yasumasa Iwasaki (Author), Katsutaro Morino (Author), Satoshi Ugi (Author), Eiichiro Nishi (Author), Akira Andoh (Author), Hiroshi Maegawa (Author)
• Format: Book
• Published: Elsevier, 2022-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: The intestine is an important organ for nutrient metabolism via absorption and endocrine systems. Nutrients regulate O-GlcNAcylation, a post-translational modification of various proteins by O-GlcNAc transferase (OGT). We have previously shown that general OGT knockout induced severe weig...