Optimization of Layered Dissolving Microneedle for Sustained Drug Delivery Using Heat-Melted Poly(Lactic-Co-glycolic Acid)

• Main Authors: Chisong Lee (Author), Jinkyung Kim (Author), Daniel Junmin Um (Author), Youseong Kim (Author), Hye Su Min (Author), Jiwoo Shin (Author), Jee Hye Nam (Author), Geonwoo Kang (Author), Mingyu Jang (Author), Huisuk Yang (Author), Hyungil Jung (Author)
• Format: Book
• Published: MDPI AG, 2021-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Dissolving microneedles (DMNs) have been used as an alternative drug delivery system to deliver therapeutics across the skin barrier in a painless manner. In this study, we propose a novel heat-melting method for the fabrication of hydrophobic poly(lactic-co-glycolic acid) (PLGA) DMNs, without the u...