Antimycobacterial Activity, Synergism, and Mechanism of Action Evaluation of Novel Polycyclic Amines against Mycobacterium tuberculosis

• Main Authors: Erika Kapp (Author), Jacques Joubert (Author), Samantha L. Sampson (Author), Digby F. Warner (Author), Ronnett Seldon (Author), Audrey Jordaan (Author), Margaretha de Vos (Author), Rajan Sharma (Author), Sarel F. Malan (Author)
• Format: Book
• Published: Hindawi Limited, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Mycobacterium tuberculosis has developed extensive resistance to numerous antimycobacterial agents used in the treatment of tuberculosis. Insufficient intracellular accumulation of active moieties allows for selective survival of mycobacteria with drug resistance mutations and accordingly promotes t...