Characterization of naphthoquinones as inhibitors of glutathione reductase and inducers of intracellular oxidative stress

• मुख्य लेखकों: Xiaowan Chen (लेखक), Yan Ma (लेखक), Ziming Yang (लेखक), Dingjie Shen (लेखक), Xia Li (लेखक), Maowei Ni (लेखक), Xiaoling Xu (लेखक), Wei Chen (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Taylor & Francis Group, 2024-12-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Glutathione reductase (GR), one of the most important antioxidant enzymes in maintaining intracellular redox homeostasis, has become a novel target to suppress cancer cell growth and metastasis. In this work, we evaluated a series of naphthoquinones (NQs) as potential GR inhibitors and elucidated th...