Characterization of naphthoquinones as inhibitors of glutathione reductase and inducers of intracellular oxidative stress

• Main Authors: Xiaowan Chen (Author), Yan Ma (Author), Ziming Yang (Author), Dingjie Shen (Author), Xia Li (Author), Maowei Ni (Author), Xiaoling Xu (Author), Wei Chen (Author)
• Format: Book
• Published: Taylor & Francis Group, 2024-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Glutathione reductase (GR), one of the most important antioxidant enzymes in maintaining intracellular redox homeostasis, has become a novel target to suppress cancer cell growth and metastasis. In this work, we evaluated a series of naphthoquinones (NQs) as potential GR inhibitors and elucidated th...