Omega-3 fatty acid intake suppresses induction of diverse autoantibody repertoire by crystalline silica in lupus-prone mice

• Main Authors: Lichchavi D. Rajasinghe (Author), Quan-Zhen Li (Author), Chengsong Zhu (Author), Mei Yan (Author), Preeti S. Chauhan (Author), Kathryn A. Wierenga (Author), Melissa A. Bates (Author), Jack R. Harkema (Author), Abby D. Benninghoff (Author), James J. Pestka (Author)
• Format: Book
• Published: Taylor & Francis Group, 2020-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Inhalation of crystalline silica (cSiO2) in the workplace is etiologically linked to lupus and other autoimmune diseases. Exposing lupus-prone NZBWF1 mice to respirable cSiO2 unleashes a vicious cycle of inflammation and cell death in the lung that triggers interferon-regulated gene expression, ecto...