Complement receptor 1 (CR1, CD35) association with susceptibility to leprosy.

• Κύριοι συγγραφείς: Gabriela Canalli Kretzschmar (Συγγραφέας), Luana Caroline Oliveira (Συγγραφέας), Renato Mitsunori Nisihara (Συγγραφέας), Thirumalaisamy P Velavan (Συγγραφέας), Sérvio Túlio Stinghen (Συγγραφέας), Ewalda R S Stahlke (Συγγραφέας), Maria Luiza Petzl-Erler (Συγγραφέας), Iara José T de Messias-Reason (Συγγραφέας), Angelica Beate Winter Boldt (Συγγραφέας)
• Μορφή: Βιβλίο
• Έκδοση: Public Library of Science (PLoS), 2018-08-01T00:00:00Z.
• Θέματα: article
• Διαθέσιμο Online: Connect to this object online.

BACKGROUND:Pathophysiological mechanisms are still incompletely understood for leprosy, an urgent public health issue in Brazil. Complement receptor 1 (CR1) binds complement fragments C3b/C4b deposited on mycobacteria, mediating its entrance in macrophages. We investigated CR1 polymorphisms, gene ex...