Complement receptor 1 (CR1, CD35) association with susceptibility to leprosy.

• Principais autores: Gabriela Canalli Kretzschmar (Autor), Luana Caroline Oliveira (Autor), Renato Mitsunori Nisihara (Autor), Thirumalaisamy P Velavan (Autor), Sérvio Túlio Stinghen (Autor), Ewalda R S Stahlke (Autor), Maria Luiza Petzl-Erler (Autor), Iara José T de Messias-Reason (Autor), Angelica Beate Winter Boldt (Autor)
• Formato: Livro
• Publicado em: Public Library of Science (PLoS), 2018-08-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

BACKGROUND:Pathophysiological mechanisms are still incompletely understood for leprosy, an urgent public health issue in Brazil. Complement receptor 1 (CR1) binds complement fragments C3b/C4b deposited on mycobacteria, mediating its entrance in macrophages. We investigated CR1 polymorphisms, gene ex...