Redox Imbalance and Oxidative DNA Damage During Isoniazid Treatment of HIV-Associated Tuberculosis: A Clinical and Translational Pharmacokinetic Study

• Main Authors: Isaac Zentner (Author), Hyun-moon Back (Author), Leonid Kagan (Author), Selvakumar Subbian (Author), Jyothi Nagajyothi (Author), Shashikant Srivastava (Author), Jotam Pasipanodya (Author), Tawanda Gumbo (Author), Gregory P. Bisson (Author), Christopher Vinnard (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BackgroundThe potential for hepatotoxicity during isoniazid-based tuberculosis (TB) treatment presents a major challenge for TB control programs worldwide. We sought to determine whether pharmacokinetic exposures of isoniazid and its metabolites were related to cellular oxidation/reduction status an...