Cilastatin protects against imipenem-induced nephrotoxicity via inhibition of renal organic anion transporters (OATs)

• Main Authors: Xiaokui Huo (Author), Qiang Meng (Author), Changyuan Wang (Author), Yanna Zhu (Author), Zhihao Liu (Author), Xiaodong Ma (Author), Xiaochi Ma (Author), Jinyong Peng (Author), Huijun Sun (Author), Kexin Liu (Author)
• Format: Book
• Published: Elsevier, 2019-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Imipenem is a carbapenem antibiotic. However, Imipenem could not be marketed owing to its instability and nephrotoxicity until cilastatin, an inhibitor of renal dehydropeptidase-I (DHP-I), was developed. In present study, the potential roles of renal organic anion transporters (OATs) in alleviating...