Cilastatin protects against imipenem-induced nephrotoxicity via inhibition of renal organic anion transporters (OATs)

Imipenem is a carbapenem antibiotic. However, Imipenem could not be marketed owing to its instability and nephrotoxicity until cilastatin, an inhibitor of renal dehydropeptidase-I (DHP-I), was developed. In present study, the potential roles of renal organic anion transporters (OATs) in alleviating...

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Main Authors: Xiaokui Huo (Author), Qiang Meng (Author), Changyuan Wang (Author), Yanna Zhu (Author), Zhihao Liu (Author), Xiaodong Ma (Author), Xiaochi Ma (Author), Jinyong Peng (Author), Huijun Sun (Author), Kexin Liu (Author)
Format: Book
Published: Elsevier, 2019-09-01T00:00:00Z.
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