Berberine Maintains the Neutrophil N1 Phenotype to Reverse Cancer Cell Resistance to Doxorubicin

• Main Authors: Shuhui Zhang (Author), Lin Zhou (Author), Mengdi Zhang (Author), Yuehua Wang (Author), Mengqi Wang (Author), Jincheng Du (Author), Wenwen Gu (Author), Fuguang Kui (Author), Jiahuan Li (Author), Shengnan Geng (Author), Gangjun Du (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

This study explores the contributions of neutrophils to chemotherapeutic resistance and berberine-regulated cancer cell sensitivity to doxorubicin (DOX). In vitro experiments, continuous DOX treatment led to the shift of HL-60 cells to N2 neutrophils and thus induced chemotherapeutic resistance. The...