An EP2 Agonist Facilitates NMDA-Induced Outward Currents and Inhibits Dendritic Beading through Activation of BK Channels in Mouse Cortical Neurons

• Main Authors: Yoshinori Hayashi (Author), Saori Morinaga (Author), Xia Liu (Author), Jing Zhang (Author), Zhou Wu (Author), Takeshi Yokoyama (Author), Hiroshi Nakanishi (Author)
• Formato: Libro
• Publicado: Hindawi Limited, 2016-01-01T00:00:00Z.
• Subjects: article
• Acceso en liña: Connect to this object online.

Prostaglandin E2 (PGE2), a major metabolite of arachidonic acid produced by cyclooxygenase pathways, exerts its bioactive responses by activating four E-prostanoid receptor subtypes, EP1, EP2, EP3, and EP4. PGE2 enables modulating N-methyl-D-aspartate (NMDA) receptor-mediated responses. However, the...