microRNA-205-5p is a modulator of insulin sensitivity that inhibits FOXO function

• Main Authors: Fanny Langlet (Author), Marcel Tarbier (Author), Rebecca A. Haeusler (Author), Stefania Camastra (Author), Eleuterio Ferrannini (Author), Marc R. Friedländer (Author), Domenico Accili (Author)
• Format: Book
• Published: Elsevier, 2018-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objectives: Hepatic insulin resistance is a hallmark of type 2 diabetes and obesity. Insulin receptor signaling through AKT and FOXO has important metabolic effects that have traditionally been ascribed to regulation of gene expression. However, whether all the metabolic effects of FOXO arise from i...