Alterations of DNA damage response pathway: Biomarker and therapeutic strategy for cancer immunotherapy

• Main Authors: Minlin Jiang (Author), Keyi Jia (Author), Lei Wang (Author), Wei Li (Author), Bin Chen (Author), Yu Liu (Author), Hao Wang (Author), Sha Zhao (Author), Yayi He (Author), Caicun Zhou (Author)
• Format: Book
• Published: Elsevier, 2021-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Genomic instability remains an enabling feature of cancer and promotes malignant transformation. Alterations of DNA damage response (DDR) pathways allow genomic instability, generate neoantigens, upregulate the expression of programmed death ligand 1 (PD-L1) and interact with signaling such as cycli...