Evaluation of the Trypanosoma brucei 6-oxopurine salvage pathway as a potential target for drug discovery.

• Главные авторы: Eva Doleželová (Автор), David Terán (Автор), Ondřej Gahura (Автор), Zuzana Kotrbová (Автор), Michaela Procházková (Автор), Dianne Keough (Автор), Petr Špaček (Автор), Dana Hocková (Автор), Luke Guddat (Автор), Alena Zíková (Автор)
• Формат: ‌
• Опубликовано: Public Library of Science (PLoS), 2018-02-01T00:00:00Z.
• Предметы: article
• Online-ссылка: Connect to this object online.

Due to toxicity and compliance issues and the emergence of resistance to current medications new drugs for the treatment of Human African Trypanosomiasis are needed. A potential approach to developing novel anti-trypanosomal drugs is by inhibition of the 6-oxopurine salvage pathways which synthesise...