Evaluation of the Trypanosoma brucei 6-oxopurine salvage pathway as a potential target for drug discovery.

• Main Authors: Eva Doleželová (Author), David Terán (Author), Ondřej Gahura (Author), Zuzana Kotrbová (Author), Michaela Procházková (Author), Dianne Keough (Author), Petr Špaček (Author), Dana Hocková (Author), Luke Guddat (Author), Alena Zíková (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2018-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Due to toxicity and compliance issues and the emergence of resistance to current medications new drugs for the treatment of Human African Trypanosomiasis are needed. A potential approach to developing novel anti-trypanosomal drugs is by inhibition of the 6-oxopurine salvage pathways which synthesise...