Improved Prediction of Endoxifen Metabolism by CYP2D6 Genotype in Breast Cancer Patients Treated with Tamoxifen

• Main Authors: Werner Schroth (Author), Stefan Winter (Author), Thomas Mürdter (Author), Elke Schaeffeler (Author), Diana Eccles (Author), Bryony Eccles (Author), Balram Chowbay (Author), Chiea C. Khor (Author), Arafat Tfayli (Author), Nathalie K. Zgheib (Author), Michel Eichelbaum (Author), Matthias Schwab (Author), Hiltrud Brauch (Author)
• Format: Book
• Published: Frontiers Media S.A., 2017-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Purpose: Prediction of impaired tamoxifen (TAM) to endoxifen metabolism may be relevant to improve breast cancer treatment, e.g., via TAM dose increase. The polymorphic cytochrome P450 2D6 (CYP2D6) strongly determines an individual's capacity for endoxifen formation, however, CYP2D6 phenotype a...