A tRNA-derived fragment from Chinese yew suppresses ovarian cancer growth via targeting TRPA1

• Main Authors: Kai-Yue Cao (Author), Tong-Meng Yan (Author), Ji-Zhou Zhang (Author), Ting-Fung Chan (Author), Jie Li (Author), Chong Li (Author), Elaine Lai-Han Leung (Author), Jin Gao (Author), Bao-Xian Zhang (Author), Zhi-Hong Jiang (Author)
• Format: Book
• Published: Elsevier, 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Drug discovery from plants usually focuses on small molecules rather than such biological macromolecules as RNAs. Although plant transfer RNA (tRNA)-derived fragment (tRF) has been associated with the developmental and defense mechanisms in plants, its regulatory role in mammals remains unclear. By...