Predictive Value of Precision-Cut Kidney Slices as an Ex Vivo Screening Platform for Therapeutics in Human Renal Fibrosis

• Main Authors: Emilia Bigaeva (Author), Nataly Puerta Cavanzo (Author), Elisabeth G. D. Stribos (Author), Amos J. de Jong (Author), Carin Biel (Author), Henricus A. M. Mutsaers (Author), Michael S. Jensen (Author), Rikke Nørregaard (Author), Anna M. Leliveld (Author), Igle J. de Jong (Author), Jan-Luuk Hillebrands (Author), Harry van Goor (Author), Miriam Boersema (Author), Ruud A. Bank (Author), Peter Olinga (Author)
• Format: Book
• Published: MDPI AG, 2020-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Animal models are a valuable tool in preclinical research. However, limited predictivity of human biological responses in the conventional models has stimulated the search for reliable preclinical tools that show translational robustness. Here, we used precision-cut kidney slices (PCKS) as a model o...