Histone Carbonylation Is a Redox-Regulated Epigenomic Mark That Accumulates with Obesity and Aging

• Main Authors: Amy K. Hauck (Author), Tong Zhou (Author), Ambuj Upadhyay (Author), Yuxiang Sun (Author), Michael B. O'Connor (Author), Yue Chen (Author), David A. Bernlohr (Author)
• Format: Book
• Published: MDPI AG, 2020-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Oxidative stress is a hallmark of metabolic disease, though the mechanisms that define this link are not fully understood. Irreversible modification of proteins by reactive lipid aldehydes (protein carbonylation) is a major consequence of oxidative stress in adipose tissue and the substrates and spe...