Evolution of Dihydropyrimidine Dehydrogenase Diagnostic Testing in a Single Center during an 8-Year Period of Time

• Main Authors: Marieke J.H. Coenen, PhD (Author), Aimée D.C. Paulussen, PhD (Author), Marc Breuer, BSc (Author), Martijn Lindhout, BSc (Author), Demis C.J. Tserpelis, BSc (Author), Anja Steyls, BSc (Author), Jörgen Bierau, PhD (Author), Bianca J.C. van den Bosch, PhD (Author)
• Format: Book
• Published: Elsevier, 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

ABSTRACT: Objective: Fluoropyrimidine treatment can be optimized based on dihydropyrimidine dehydrogenase (DPD) activity. DPD dysfunction leads to increased exposure to active metabolites, which can result in severe or even fatal toxicity. Methods: We provide an overview of 8 years of DPD diagnostic...