Zein-Stabilized Nanospheres as Nanocarriers for Boosting the Aphrodisiac Activity of Icariin: Response Surface Optimization and In Vivo Assessment

• Main Authors: Hani Z. Asfour (Author), Nabil A. Alhakamy (Author), Usama A. Fahmy (Author), Osama A. A. Ahmed (Author), Waleed Y. Rizg (Author), Raed I. Felimban (Author), Ashraf B. Abdel-Naim (Author), Mohammad A. S. Abourehab (Author), Rasha A. Mansouri (Author), Ulfat M. Omar (Author), Shaimaa M. Badr-Eldin (Author)
• Format: Book
• Published: MDPI AG, 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Icariin (ICA), a main active compound of the Epimedium genus, is used as an aphrodisiac in traditional Chinese herbal medicine. Despite its therapeutic efficacy, ICA displays reduced oral absorption, and therefore, low bioavailability hindered its clinical application. Implementing nanotechnology in...