Opioid Drug-Drug-Drug Interactions and Unintentional Traumatic Injury: Screening to Detect Three-Way Drug Interaction Signals

• Main Authors: Emily K. Acton (Author), Sean Hennessy (Author), Colleen M. Brensinger (Author), Warren B. Bilker (Author), Todd A. Miano (Author), Sascha Dublin (Author), John R. Horn (Author), Sophie Chung (Author), Douglas J. Wiebe (Author), Allison W. Willis (Author), Charles E. Leonard (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Growing evidence suggests that drug interactions may be responsible for much of the known association between opioid use and unintentional traumatic injury. While prior research has focused on pairwise drug interactions, the role of higher-order (i.e., drug-drug-drug) interactions (3DIs) has not bee...