High-yield synthesis and purification of recombinant human GABA transaminase for high-throughput screening assays

• Main Authors: Mingu Gordon Park (Author), Ah-reum Han (Author), Su Yeon Kim (Author), Tai Young Kim (Author), Ho Min Kim (Author), C. Justin Lee (Author)
• Format: Book
• Published: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Many studies have focussed on modulating the activity of γ-aminobutyric acid transaminase (GABA-T), a GABA-catabolizing enzyme, for treating neurological diseases, such as epilepsy and drug addiction. Nevertheless, human GABA-T synthesis and purification have not been established. Thus, biochemical...