Deletion of arrestin-3 does not reduce drug-seeking behavior in a longitudinal paradigm of oral morphine self-administration

• Main Authors: Sarah Warren Gooding (Author), Lindsey Felth (Author), Randi Foxall (Author), Zachary Rosa (Author), Kyle Ireton (Author), Izabella Sall (Author), Joshua Gipoor (Author), Anirudh Gaur (Author), Madeline King (Author), Noah Dirks (Author), Cheryl Allyne Whistler (Author), Jennifer Lynne Whistler (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

IntroductionOpioid drugs are potent analgesics that mimic the endogenous opioid peptides, endorphins and enkephalins, by activating the µ-opioid receptor. Opioid use is limited by side effects, including significant risk of opioid use disorder. Improvement of the effect/side effect profile of opioid...