A ß-Secretase Modulator Decreases Tau Pathology and Preserves Short-Term Memory in a Mouse Model of Neurofibrillary Degeneration

• Main Authors: Marie Tautou (Author), Sabiha Eddarkaoui (Author), Florian Descamps (Author), Paul-Emmanuel Larchanché (Author), Jamal El Bakali (Author), Liesel Mary Goveas (Author), Mélanie Dumoulin (Author), Chloé Lamarre (Author), David Blum (Author), Luc Buée (Author), Patricia Melnyk (Author), Nicolas Sergeant (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Identifying which among several in cellulo pharmacological activities is necessary for the proper in vivo activity is essential for further drug development against Alzheimer's disease pathophysiological processes. An in-depth structure-activity relationship-based study has been carried out, an...