Improving cancer immunotherapy via co-delivering checkpoint blockade and thrombospondin-1 downregulator

• Main Authors: Qingqing Xiao (Author), Xiaotong Li (Author), Chang Liu (Author), Yuxin Jiang (Author), Yonglong He (Author), Wanting Zhang (Author), Helena S. Azevedo (Author), Wei Wu (Author), Yuanzheng Xia (Author), Wei He (Author)
• Format: Book
• Published: Elsevier, 2023-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The use of checkpoint-blockade antibodies is still restricted in several malignancies due to the modest efficacy, despite considerable success in anti-tumor immunotherapy. The poor response of cancer cells to immune destruction is an essential contributor to the failure of checkpoint therapy. We hyp...