Posiphen Reduces the Levels of Huntingtin Protein through Translation Suppression

• Main Authors: Xu-Qiao Chen (Author), Carlos A. Barrero (Author), Rodrigo Vasquez-Del Carpio (Author), E. Premkumar Reddy (Author), Chiara Fecchio (Author), Salim Merali (Author), Alessia Deglincerti (Author), Cheng Fang (Author), Jack Rogers (Author), Maria L. Maccecchini (Author)
• Format: Book
• Published: MDPI AG, 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Posiphen tartrate (Posiphen) is an orally available small molecule that targets a conserved regulatory element in the mRNAs of amyloid precursor protein (APP) and α-synuclein (αSYN) and inhibits their translation. APP and αSYN can cause neurodegeneration when their aggregates induce neurotoxicity. T...