Posiphen Reduces the Levels of Huntingtin Protein through Translation Suppression

• Κύριοι συγγραφείς: Xu-Qiao Chen (Συγγραφέας), Carlos A. Barrero (Συγγραφέας), Rodrigo Vasquez-Del Carpio (Συγγραφέας), E. Premkumar Reddy (Συγγραφέας), Chiara Fecchio (Συγγραφέας), Salim Merali (Συγγραφέας), Alessia Deglincerti (Συγγραφέας), Cheng Fang (Συγγραφέας), Jack Rogers (Συγγραφέας), Maria L. Maccecchini (Συγγραφέας)
• Μορφή: Βιβλίο
• Έκδοση: MDPI AG, 2021-12-01T00:00:00Z.
• Θέματα: article
• Διαθέσιμο Online: Connect to this object online.

Posiphen tartrate (Posiphen) is an orally available small molecule that targets a conserved regulatory element in the mRNAs of amyloid precursor protein (APP) and α-synuclein (αSYN) and inhibits their translation. APP and αSYN can cause neurodegeneration when their aggregates induce neurotoxicity. T...