Self-replicating RNA nanoparticle vaccine elicits protective immune responses against SARS-CoV-2

• Main Authors: Guibin Lin (Author), Huan Yan (Author), Jing Sun (Author), Jincun Zhao (Author), Yuan Zhang (Author)
• Formato: Livro
• Publicado em: Elsevier, 2023-06-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

The creation of safe and effective vaccines that induce potent cellular and humoral immune responses against SARS-CoV-2 is urgently needed to end the global COVID-19 epidemic. Here, we developed an alphavirus-derived self-replicating RNA (repRNA)-based vaccine platform encoding the receptor-binding...