Self-replicating RNA nanoparticle vaccine elicits protective immune responses against SARS-CoV-2

• Päätekijät: Guibin Lin (Tekijä), Huan Yan (Tekijä), Jing Sun (Tekijä), Jincun Zhao (Tekijä), Yuan Zhang (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: Elsevier, 2023-06-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

The creation of safe and effective vaccines that induce potent cellular and humoral immune responses against SARS-CoV-2 is urgently needed to end the global COVID-19 epidemic. Here, we developed an alphavirus-derived self-replicating RNA (repRNA)-based vaccine platform encoding the receptor-binding...