Tetraethylenepentamine-Coated β Cyclodextrin Nanoparticles for Dual DNA and siRNA Delivery

• Main Authors: Chi-Hsien Liu (Author), Pei-Yin Shih (Author), Cheng-Han Lin (Author), Yi-Jun Chen (Author), Wei-Chi Wu (Author), Chun-Chao Wang (Author)
• Format: Book
• Published: MDPI AG, 2022-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Nucleic acid reagents, including plasmid-encoded genes and small interfering RNA (siRNA), are promising tools for validating gene function and for the development of therapeutic agents. Native β-cyclodextrins (BCDs) have limited efficiency in gene delivery due to their instable complexes with nuclei...