Exatecan Antibody Drug Conjugates Based on a Hydrophilic Polysarcosine Drug-Linker Platform

Exatecan Antibody Drug Conjugates Based on a Hydrophilic Polysarcosine Drug-Linker Platform

We herein report the development and evaluation of a novel HER2-targeting antibody-drug conjugate (ADC) based on the topoisomerase I inhibitor payload exatecan, using our hydrophilic monodisperse polysarcosine (PSAR) drug-linker platform (PSARlink). In vitro and in vivo experiments were conducted in...

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Main Authors: Louise Conilh (Author), Guy Fournet (Author), Eric Fourmaux (Author), Angélique Murcia (Author), Eva-Laure Matera (Author), Benoît Joseph (Author), Charles Dumontet (Author), Warren Viricel (Author)
Format: Book
Published: MDPI AG, 2021-03-01T00:00:00Z.
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