Metformin Shortens Prolonged QT Interval in Diabetic Mice by Inhibiting L-Type Calcium Current: A Possible Therapeutic Approach

• Main Authors: Hui Wang (Author), Cao Wang (Author), Yuan Lu (Author), Yan Yan (Author), Dongjing Leng (Author), Shanshan Tian (Author), Dongjie Zheng (Author), Zhiguo Wang (Author), Yunlong Bai (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The incidence and mortality of cardiovascular disease in diabetic patients are 2-3 times higher than those in non-diabetic patients. Abnormal function of the L-type calcium channel in myocardial tissue might result in multiple cardiac disorders such as a prolonged QT interval. Therefore, QT prolonga...