Determining mutational burden and signature using RNA-seq from tumor-only samples

Abstract Background Traditionally, mutational burden and mutational signatures have been assessed by tumor-normal pair DNA sequencing. The requirement of having both normal and tumor samples is not always feasible from a clinical perspective, and led us to investigate the efficacy of using RNA seque...

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Main Authors: Erik Jessen (Author), Yuanhang Liu (Author), Jaime Davila (Author), Jean-Pierre Kocher (Author), Chen Wang (Author)
Formato: Libro
Publicado: BMC, 2021-03-01T00:00:00Z.
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