Infection with chikungunya virus confers heterotypic cross-neutralizing antibodies and memory B-cells against other arthritogenic alphaviruses predominantly through the B domain of the E2 glycoprotein.

• Main Authors: John M Powers (Author), Zoe L Lyski (Author), Whitney C Weber (Author), Michael Denton (Author), Magdalene M Streblow (Author), Adam T Mayo (Author), Nicole N Haese (Author), Chad D Nix (Author), Rachel Rodríguez-Santiago (Author), Luisa I Alvarado (Author), Vanessa Rivera-Amill (Author), William B Messer (Author), Daniel N Streblow (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2023-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Infections with Chikungunya virus, a mosquito-borne alphavirus, cause an acute febrile syndrome often followed by chronic arthritis that persists for months to years post-infection. Neutralizing antibodies are the primary immune correlate of protection elicited by infection, and the major goal of va...