Cardiomyocytes, cardiac endothelial cells and fibroblasts contribute to anthracycline-induced cardiac injury through RAS-homologous small GTPases RAC1 and CDC42

• मुख्य लेखकों: Pelin Kücük (लेखक), Lena Abbey (लेखक), Joachim Schmitt (लेखक), Christian Henninger (लेखक), Gerhard Fritz (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Elsevier, 2024-05-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

The clinical use of the DNA damaging anticancer drug doxorubicin (DOX) is limited by irreversible cardiotoxicity, which depends on the cumulative dose. The RAS-homologous (RHO) small GTPase RAC1 contributes to DOX-induced DNA damage formation and cardiotoxicity. However, the pathophysiological relev...