Effect of CYP3A4/5, ABCB1 gene polymorphisms on the residual equilibrium concentration of apixaban and bleeding in patients with non-valvular atrial fibrillation and deep vein thrombosis

• Main Authors: l. V. Fedina (Author), i. N. Sychev (Author), K. V. Mirzaev (Author), A. V. Vardanyan (Author), S. V. Glagolev (Author), A. A. Kachanova (Author), P. O. Bochkov (Author), R. V. Shevchenko (Author), S. N. Tuchkova (Author), I. V. Sychev (Author), S. P. Abdullaev (Author), D A. Sychev (Author)
• Format: Book
• Published: Столичная издательская компания, 2024-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Aim. The aim of our study was to investigate the influence of polymorphic markers of CYP3A4*22 CYP3A4*22 (c.522-191C>T, rs35599367), CYP3A5*3 (c.219237A>G, rs776746), ABCB1 rs1045642 (c.3435T>C) and rs4148738 (c.2692-2236C>T) genes on the plasma concentration of apixaban, on changes in p...