Exploring the potential of flubendazole in filariasis control: evaluation of the systemic exposure for different pharmaceutical preparations.

• Main Authors: Laura Ceballos (Author), Charles Mackenzie (Author), Timothy Geary (Author), Luis Alvarez (Author), Carlos Lanusse (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2014-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The goal of elimination of the human filariases would benefit greatly from the use of a macrofilaricidal agent. In vivo trials in humans and many experimental animal models suggest that flubendazole (FLBZ) is a highly efficacious macrofilaricide. However, since serious injection site reactions were...