Micelle-Forming Block Copolymers Tailored for Inhibition of P-gp-Mediated Multidrug Resistance: Structure to Activity Relationship

• 主要な著者: Alena Braunová (著者), Martin Kaňa (著者), Júlia Kudláčová (著者), Libor Kostka (著者), Jan Bouček (著者), Jan Betka (著者), Milada Šírová (著者), Tomáš Etrych (著者)
• フォーマット: 図書
• 出版事項: MDPI AG, 2019-11-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Multidrug resistance (MDR) is often caused by the overexpression of efflux pumps, such as ABC transporters, in particular, P-glycoprotein (P-gp). Here, we investigate the di- and tri- block amphiphilic polymer systems based on polypropylene glycol (PPO) and copolymers of (<i>N</i>-(2-hyd...