Micelle-Forming Block Copolymers Tailored for Inhibition of P-gp-Mediated Multidrug Resistance: Structure to Activity Relationship

• Main Authors: Alena Braunová (Author), Martin Kaňa (Author), Júlia Kudláčová (Author), Libor Kostka (Author), Jan Bouček (Author), Jan Betka (Author), Milada Šírová (Author), Tomáš Etrych (Author)
• Format: Book
• Published: MDPI AG, 2019-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Multidrug resistance (MDR) is often caused by the overexpression of efflux pumps, such as ABC transporters, in particular, P-glycoprotein (P-gp). Here, we investigate the di- and tri- block amphiphilic polymer systems based on polypropylene glycol (PPO) and copolymers of (<i>N</i>-(2-hyd...